Fig. 1.

Pharmacological isolation of AMPA receptors. (A) Sample traces of EPSCs with continuously added specific antagonist such as APV (NMDA receptor antagonist, 50 µM), and IEM-1460 (GluR2-lacking AMPA receptor blocker, 100 µM), respectively. (B) Plot graph shows baseline, addition of APV, and IEM-1460 by 10 min interval, tendency decreased EPSCs by APV and IEM-1460 (n=6). (C) Bar graph shows average peak data normalized to control (open bar) currents. ^*p<0.05, when compared to control versus APV and APV versus IEM-1460. (D) Bar graph shows NMDA/AMPA ratio and GluR2-lacking AMPA receptor/GluR2-containing AMPA receptor ratio calculated by data from Fig. 1C. Data are expressed as mean±S.E.M.