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. Author manuscript; available in PMC: 2009 Oct 26.
Published in final edited form as: Int J Cancer. 2008 Mar 1;122(5):1068–1076. doi: 10.1002/ijc.23228

Figure 2.

Figure 2

Gastric histopathology of H. pylori infection in gulo−/− with low vitamin C supplementation (a, d, g) or high vitamin C supplementation (b, e, h) versus C57BL/6 (WT) controls (c, f, i). (a–c) No significant lesions developed in uninfected mice in any group at 32 weeks. (d–f) Equivalent gastric lesions developed in all H. pylori-infected groups at 16 WPI, although gulo−/− mice with low vitamin C supplementation (d) exhibited a trend for less severe epithelial defects, foveolar hyperplasia and dysplasia. (g–i) Equivalent gastric inflammation developed in all groups at 32 WPI, although gulo−/− mice with low vitamin C supplementation (g) had less severe epithelial defects, mucous metaplasia and foveolar hyperplasia.