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. Author manuscript; available in PMC: 2010 Oct 15.
Published in final edited form as: Cancer Res. 2009 Oct 13;69(20):8166–8174. doi: 10.1158/0008-5472.CAN-08-3856

Figure 1.

Figure 1

Gastric histology in mice. At 32-34 weeks old, uninfected male mice exhibited spontaneous gastric epithelial dysplasia with inflammation (a). H. pylori infection significantly increased inflammation, oxyntic atrophy, foveolar hyperplasia, and dysplasia in the corpus of age-matched male mice at 28 (WPI) (b). Sulindac treatment exacerbated inflammation but not hyperplasia or dysplasia in H. pylori-infected mice (c). H. pylori antimicrobial therapy and sulindac significantly reduced inflammation, oxyntic atrophy, foveolar hyperplasia, and dysplasia (d). Tissues were stained with H&E; bar = 400 μM.