Table 2.
Annualized rates of change in measures of cognitive function, 1H MRS metabolite ratios*, and ventricular volume*
| Control | All aMCI | aMCI-stable | aMCI-converter | AD | |
|---|---|---|---|---|---|
| N | 85 | 49 | 31 | 18 | 60 |
| NAA/Cr APC Mean (SD) | 0.5 (4.3) | −1.4 (6.1) | −1.1 (5.5) | −2.0 (7.3) | −1.8 (7.0) |
| Cho/Cr APC Mean (SD) | 2.6 (8.0) | −1.3 (10.9) | −3.7 (10.6) | 2.8 (10.7) | 1.2 (9.8) |
| mI/Cr APC Mean (SD) | 1.9 (8.0) | 0.7 (10.0) | 0.0 (10.2) | 2.6 (8.7) | 0.8 (7.7) |
| Ventricular volume APC Mean (SD) | 2.4 (1.9) | 3.5 (2.8) | 2.8 (2.8) | 4.8 (2.5) | 5.8 (3.5) |
| MMSE annualized change Median (IQR) | 0.0 (−0.7, 0.7) | −1.0 (−1.5, 0.0) | 0.0 (−1.0, 0.0) | −1.8 (−3.0, −1.1) | −2.2 (−4.8, 0.0) |
| DRS annualized change Median (IQR) | 0.6 (−0.8, 1.9) | −1.0 (−3.0, 1.5) | −1.0 (−2.6, 2.0) | −1.3 (−7.3, 0.7) | −6.1 (−13.8, −1.9) |
| CDR annualized change Median (IQR) | 0.00 (0.0, 0.0) | 0.4 (0.0, 1.8) | 0.0 (0.0, 0.4) | 2.2 (1.5, 3.0) | 1.6 (0.0, 3.6) |
APC: annual percent change, IQR: inter-quartile range, MMSE: Mini Mental State Examination, DRS: Dementia Rating Scale, CDR: Clinical Dementia Rating Sum of Boxes, aMCI: amnestic mild cognitive impairment, AD: Alzheimer’s Disease
*
Annualized rates of change in 1H MRS metabolite ratios and ventricular volume reported at a mean age of 78 yrs.