TABLE 1.

Mean Pharmacokinetic Parameters of 50 mg/kg GHB Given Alone and in Combination With Ethanol

	Cmax (μg/mL)	Tmax (min)	t1/2 (min)	AUC (μg· min/mL)	Clearance (mL/min· kg)	Renal Clearance (mL/min)	% Dose Recovered in Urine in 24 Hours
GHB alone	72.6 ± 16.2	57.2 ± 12.5	51.8 ± 21.3	9330 ± 3390	6.2 ± 2.7	17.8 ± 13.1	4.8 ± 3.1
GHB with ethanol	84.0 ± 25.8	54.0 ± 27.9	67.0 ± 48.4	11,360 ± 4796	5.0 ± 2.4	19.3 ± 17.4	5.0 ± 4.1

Values are expressed as means (n = 16) ± standard deviations. All comparisons were not statistically significant (P > 0.05).