Table 1.
Zinc-Dependent Histone Deacetylases
| HDAC | Localization | Size (AA) | Chromosomal site | Tissue distribution* |
|---|---|---|---|---|
| Class I | ||||
| HDAC1 | Nucleus | 483 | 1p34.1 | ubiquitous |
| HDAC2 | Nucleus | 488 | 6p21 | ubiquitous |
| HDAC3 | Nucleus | 423 | 5q31 | ubiquitous |
| HDAC8 | Nucleus | 377 | Xq13 | ubiquitous |
| CLASS IIa | ||||
| HDAC4 | Nuc/Cyt | 1084 | 2q372 | H, SM, B |
| HDAC5 | Nuc/Cyt | 1122 | 17q21 | H, SM, B |
| HDAC7 | Nuc/Cyt | 855 | 12q13 | H, PL, PA, SM |
| HDAC9 | Nuc/Cyt | 1011 | 7p21-p15 | SM, B |
| Calss IIb | ||||
| HDAC6 | Mainly Cyt | 1215 | Xp11.22–33 | H, L, K, PA |
| HDAC10 | Mainly Cyt | 669 | 22q13.31–33 | L, S, K |
| Class V | ||||
| HDAC11 | Nuc/Cyt | 347 | 3p25.2 | B, H, SM, K |
*
SM=skeletal muscle; B=brain; PL=platelet; L=liver; K=kidney; S=spleen; H=heart; PA=pancreas.