Table 2.

Substrates of histone deacetylases (partial list)^*

Pathway	Protein
HDACs	HDAC1 and ? other HDACs
Cell motility	α-tubulin, cortactin
Chaperones	HSAP90, HSP70
Gene transcription factors and co-regulators	P53, p73, GATA-1, 2 and 3, MyoD, E2F1, 2 and 3, PLAG-1 and PLAGL-2, c-myc, BCL-2, Rb, PGC-α
Chromatin structure	HMG-A1, B1, B2, N1 and N2, SRY
Nuclear receptors (DNA)	Androgen receptor, glucocorticoid receptor, estrogen receptor α
Signaling mediators	SAT3, Smad7, β-Catenin
DNA repair	Ku70, WRN
Nuclear import	Importin-α7
Inflammation mediator	HMGB1
Viral protein	E1A, L-HDAg, S-HDAg

^*See text for references.