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. Author manuscript; available in PMC: 2009 Oct 26.
Published in final edited form as: Cancer Res. 2008 Sep 15;68(18):7278–7282. doi: 10.1158/0008-5472.CAN-08-1842

Figure 2.

Figure 2

Local but not remote wounding promotes tumor growth in a T-cell dependent fashion. A. In contrast to local wounding, remote wounding by suprascapular dermal incision does not significantly alter the cumulative tumor mass as measured by AUC in an orthotopic syngeneic mouse model of breast cancer (Kruskal-Wallis Test / Dunn's Multiple Comparison Analysis). B. Local wounding but not induction of a systemic acute phase response by injection of turpentine (30μl) into the suprascapular pocket 9 days after tumor cell inoculation into the mammary fat pads IV/V and IX/X significantly increases the cumulative tumor mass (AUC, Kruskal-Wallis Test / Dunn's Multiple Comparison Analysis). C. In nude mice (BALB/c nu/nu) local wounding does not promote tumor growth (Mann-Whitney Test). D. Daily injection of wound fluid (40μl) into the proximity of tumor cell inoculation sites starting 9 days after tumor cell inoculation significantly increased the cumulative tumor mass (AUC) as compared to injection of DPBS (Mann-Whitney Test). Bars indicate medians.