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“DNA structure-specific cleavage” model. A non-B DNA structure formed on non-damaged DNA (shown in the figure as a Z-DNA structure) can be mistakenly recognized as a site of damage. The recruited DNA repair machinery generates breaks within or surrounding the non-B DNA structure, followed by error-generating repair of the breaks. This “structure forming-repair” cycle can occur repeatedly as a futile cycle until the sequence is mutated.
