TABLE 1.
Demographic and Clinical Characteristics of Male Patients With First-Episode Schizophrenia or Affective Psychosis and Healthy Comparison Subjects Who Underwent High-Spatial-Resolution MRI Measurement of Temporal Lobe Gray Matter Volumes
| Analysis |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Patients With Schizophrenia (N=20) | Patients With Affective Psychosis (N=20) | Healthy Comparison Subjects (N=23) | Statistic | df | p | |||
| Mean | SD | Mean | SD | Mean | SD | F | |||
| Agea (years) | 25.3 | 7.4 | 22.5 | 5.2 | 25.1 | 4.3 | 1.767 | 2, 60 | 0.180 |
| Handednessb | 0.81 | 0.16 | 0.74 | 0.16 | 0.79 | 0.17 | 0.994 | 2, 60 | 0.376 |
| Socioeconomic statusc | 3.5 | 1.4 | 2.8 | 1.3 | 2.4 | 1.0 | 4.019 | 2, 60 | 0.023 |
| Parents’ socioeconomic statusc | 1.8 | 0.6 | 1.5 | 0.8 | 1.4 | 0.6 | 2.368 | 2, 60 | 0.102 |
| Mini-Mental State Examination | 28.0 | 2.7 | 29.1 | 1.3 | 29.1 | 1.2 | 2.310 | 2, 60 | 0.108 |
| WAIS-R information subscale score | 11.6 | 3.3 | 13.2 | 2.8 | 13.1 | 2.4 | 1.947 | 2, 60 | 0.152 |
| WAIS-R digit span subscale score | 10.4 | 3.2 | 10.6 | 2.7 | 11.3 | 3.2 | 0.515 | 2, 60 | 0.600 |
| t | |||||||||
| Brief Psychiatric Rating Scale score | 37.3 | 12.3 | 31.1 | 8.0 | 1.884 | 39 | 0.067 | ||
| Global Assessment Scale score | 36.4 | 7.8 | 41.8 | 11.3 | −1.759 | 39 | 0.087 | ||
| Age at first medication | 25.4 | 7.3 | 22.8 | 5.2 | 1.187 | 31 | 0.244 | ||
| Antipsychotic medication dose (mg/day in chlorpromazine equivalents) | 313.1 | 426.7 | 168.8 | 130.3 | 1.444 | 39 | 0.157 | ||
a
Range, 18–41 years for the patient groups and 18–35 years for the comparison group.
b
Edinburgh Inventory scores; ranges, 0.41–1.00 for the schizophrenia group, 0.44–1.00 for the affective psychosis group, and 0.47–1.00 for the comparison group.
c
Higher scores indicate lower socioeconomic status. Socioeconomic status was significantly lower for the schizophrenia group than for comparison subjects (Tukey’s honestly significant difference test, p=0.011).