Table 2.

TFs Controlling Chemosensory Neuron Differentiation Exhibit Higher Levels of Radical Nonsynonymous/Synonymous (d_R/d_S) and Conservative Nonsynonymous/Synonymous (d_C/d_S) Rate Ratios Than Structural Chemosensory Genes

	dR/dS		dC/dS
Chemical Classification	TF	Structural	TF	Structural
Charge	0.0471 ± 0.006	0.0325 ± 0.003*	0.1084 ± 0.008	0.0586 ± 0.005***
Polarity	0.0793 ± 0.007	0.0361 ± 0.004***	0.0849 ± 0.007	0.0554 ± 0.004***
Volume & polarity	0.0587 ± 0.005	0.0360 ± 0.003***	0.1347 ± 0.011	0.0748 ± 0.006***
Charge &aromatic	0.0498 ± 0.005	0.0369 ± 0.003*	0.1209 ± 0.010	0.0619 ± 0.005***
Charge & polarity	0.0635 ± 0.006	0.0359 ± 0.003***	0.1193 ± 0.009	0.0677 ± 0.005***

NOTE.—Mean ± 1 standard error. Significance is obtained from a nonparametric Wilcoxon two-sample test: *P < 0.05, **P < 0.01, and ***P < 0.001. The list of TFs used in this analysis is reported in supplementary table 3, Supplementary Material online.

The radical and conservative amino acid changes are based on five amino acid chemical classifications. Caenorhabditis remanei and Caenorhabditis briggsae were used to compute divergence.