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Simulation of drug levels for diclofenac sodium solution dosage in the vitreous and RC of Dutch belted rabbits by using the final parameters mentioned in Table 3 obtained from model 1A (Fig. 4A). (A) Simulated drug levels for a 10-mg solution of diclofenac sodium and comparison with observed levels for 10 mg diclofenac acid suspension. Simulated (B) vitreous and (C) RC drug levels for diclofenac sodium solutions of 0.5, 0.75, and 1.5 mg.
