Table 3.
Final Parameter Estimates for the Best-Fit Pharmacokinetic Models of Diclofenac Sodium and Diclofenac Acid Suspension Injection
| Diclofenac Sodium Solution (0.3 mg) |
Diclofenac Acid Suspension (10 mg) |
||
|---|---|---|---|
| Parameter (units) | Estimate Value | Parameter (units) | Estimate Value |
| K12 (h–1) | 0.4159 | K12 (h–1) | 25.8354 |
| Vvit (mL) | 3.1585 | Vvit (mL) | 188.489 |
| K20 (h–1) | 7.9423 | K20 (h–1) | 12.0709 |
| Vret (g) | 2.1685 | Vret (g) | 59.6416 |
| K13 (h–1) | 0.2889 | ||
| K31 (h–1) | 0.0042 | ||
| K24 (h–1) | 0.7106 | ||
| K42 (h–1) | 0.0174 | ||
The models were developed with Berkeley-Madonna software (University of California, Berkeley). Models 1A and 2C were the best-fit models for diclofenac sodium solution and diclofenac acid suspension, respectively.