Table 2.

Plasma amino acid concentrations (μM) in lean and ob/ob mice

	Fed			Fasted
	lean	ob/ob		lean	ob/ob
ASP	12.4 ± 1.3	14.1 ± 1.2	ns	9.7 ± 0.7	11.7 ± 1.0	ns
GLU	46.3 ± 5.1	62.5 ± 7.6	ns	32.8 ± 2.7	59.5 ± 6.9**	81%
ASN	41.7 ± 2.3	54.8 ± 4.0**	31%	55.5 ± 4.3	42.7 ± 2.1*	−23%
SER	117.8 ± 4.8	152.6 ± 12.2*	30%	122.2 ± 12.1	98.9 ± 2.8	ns
GLN	606.7 ± 35.2	614.9 ± 17.1	ns	640.7 ± 38.9	671.7 ± 13.8	ns
HIS	60.2 ± 3.2	72.7 ± 5.4	ns	67.8 ± 8.3	55.3 ± 5.6	ns
GLY	253.8 ± 14.8	210.2 ± 22.3	ns	242.1 ± 16.5	164.0 ± 6.9**	−32%
THR	150.6 ± 5.8	197.7 ± 12.9**	31%	163.9 ± 14.3	110.4 ± 4.7**	−33%
CIT	51.4 ± 3.2	71.4 ± 2.0***	39%	48.0 ± 3.1	52.3 ± 3.4	ns
ARG	131.4 ± 9.2	99.9 ± 7.7*	−24%	125.2 ± 9.9	29.4 ± 4.6**	−77%
B-ALA	9.5 ± 0.6	7.8 ± 0.6	ns	2.0 ± 1.0	1.1 ± 0.6	ns
TAU	445.6 ± 38.8	637.8 ± 53.7**	43%	701.7 ± 48.2	735.3 ± 86.9	ns
ALA	390.6 ± 18.1	583.3 ± 48.1**	49%	326.1 ± 19.4	272.7 ± 16.4*	−16%
TYR	78.4 ± 3.7	125.3 ± 7.8***	60%	62.7 ± 3.0	58.3 ± 1.5	ns
TRP	76.6 ± 5.6	123.0 ± 5.2***	60%	67.9 ± 5.3	129.6 ± 3.3**	91%
MET	66.1 ± 3.7	74.5 ± 4.7	ns	66.4 ± 3.8	42.5 ± 1.4**	−36%
VAL	166.3 ± 7.4	282.4 ± 17.5***	70%	178.6 ± 14.4	215.8 ± 12.7	ns
PHE	65.0 ± 3.2	101.4 ± 5.2***	56%	85.4 ± 4.2	78.7 ± 1.7	ns
ILE	68.7 ± 3.8	126.2 ± 7.2***	84%	79.9 ± 6.8	101.0 ± 5.9*	26%
LEU	144.2 ± 5.3	234.5 ± 17.5***	63%	157.3 ± 14.7	177.7 ± 9.4	ns
ORN	96.8 ± 4.2	190.3 ± 9.6***	96%	73.8 ± 12.1	173.6 ± 5.6**	135%
LYS	307.3 ± 23.0	323.0 ± 15.2	ns	299.0 ± 15.4	209.4 ± 7.6**	−30%

Values are means ± SE.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001 compared with lean mice in each nutritional state; ns donates not significant, n=8/group