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. Author manuscript; available in PMC: 2009 Oct 26.
Published in final edited form as: Structure. 2008 Aug 6;16(8):1166–1174. doi: 10.1016/j.str.2008.04.012

Figure 3. Analysis of FdI:A and FdI:T Base Pairs.

Figure 3

(A and B) Structure of FdI base paired with (A) adenine and (B) thymine. The nucleotides are represented as sticks; atoms are colored as follows: carbon, green; nitrogen, blue; oxygen, red; phosphate, orange; and fluorine, cyan. The Fo − Fc electron density map of the base pair is represented as a mesh contoured at 3σ. Black, dotted lines represent hydrogen bonds.

(C) Effect of 2′-fluorine substitution on the deoxyribose sugar pucker of the FdI base. The color scheme is as in (A).

(D) Stick representation of the FdI base and the neighboring base, T9, illustrating the microenvironment of the 2′-fluorine atom. Dotted lines indicate distances from the 2′-fluorine to the three nearest atoms. All representations are from the FdI:A structure.