Table 1.
Origin, Culture Conditions and Functional Properties of Different Pluripotent Stem Cell Lines
| Cell line | Origin | Growth factor conditions | Tertoma formation | Chimera formation | Reference |
|---|---|---|---|---|---|
| Murine ES | Blastocyst | LIF, BMP4 | All germ layers | Somatic and germline contribution | (Evans and Kaufman, 1981; Martin, 1981; Martin and Evans, 1975) |
| Murine EpiSC | Epiblast | bFGF, Activin | All germ layers | No | (Brons et al., 2007; Tesar et al., 2007) |
| Human ES | Blastocyst | bFGF, Activin, (BIO), MEF conditioned media | All germ layers | Not Tested | (Thomson et al., 1998) |
| FAB-SC | Blastocyst | bFGF, Activin, BIO | No | No | This report |
| LIF/BMP4 stimulated FAB-SC | Blastocyst | LIF, BMP4 | All germ layers | Somatic and germline contribution | This Report |
| Reverted FAB-SC | Blastocyst | bFGF, Activin, BIO | All germ layers | Somatic contribution, germline contribution not tested | This Report |
| Murine IPS cells | Somatic cells | LIF, BMP4 | All germ layers | Somatic and germline contribution | (Maherali et al., 2007; Meissner et al., 2007; Okita et al., 2007; Takahashi and Yamanaka, 2006) |
| Human IPS cells | Somatic cells | bFGF, serum, MEF conditioned media | All germ layers | Not tested | (Park et al., 2008; Takahashi et al., 2007; Yu et al., 2007) |
| Murine EG cells | Embryonic gonad | Derivation: bFGF, LIF and SCF Maintenance: LIF and fetal bovine serum |
All germ layers | Somatic and germline contribution | (Matsui et al., 1992; Resnick et al., 1992) |
| Human EG cells | Embryonic gonad | LIF, bFGF and Forskolin | All germ layers | Not Tested | (Shamblott et al., 1998) |
| Murine mGS cells | Post-natal testis | Derivation: GDNF, LIF Maintenance: LIF and fetal bovine serum |
All germ layers | Somatic contribution | (Guan et al., 2006; Kanatsu-Shinohara et al., 2004; Seandel et al., 2007) |