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Experimental hyperalgesia exemplified by capsaicin-evoked hyperalgesia in the skin. The stars illustrate how sensitization of the pain system is evoked at peripheral (arm) and central levels (spinal and supraspinal). The picture illustrates (top left) how hyperalgesia is manifested locally (peripheral sensitisation in the area of flare formation) and by central sensitization (allodynia and hyperalgesia to pinprick)
