Category	Description
Potential clinical relevance
A	No inconvenience, insignificant effect
B	Short-lived inconvenience (<24–48 h) without residual symptoms
C	Long-lived inconvenience (48–168 h) without residual symptoms
D	Long-lived inconvenience (>168 h) with residual symptoms or handicap
E	Potential failure of life-saving therapy, increased risk of pregnancy (without risks concerning mother and/or fetus), cardiac arrhythmia, rhabdomyolysis, malignant hypertension, pseudopheochromocytome, multiorgan failure
F	Death, torsade de pointes, ventricular arrhythmia, myocardial infarction, serotonin syndrome, hyperpyrexia (42°C)
Quality of evidence
4	Controlled, published study with clinically relevant end-points
3	Controlled, published study with relevant surrogate end-points
2	Well-documented, published case reports; analysis of case series
1	Incomplete, published case reports
0	Animal studies, in vitro studies, data on file
-	No evidence
	Not classified