Table 1b.
Estimated population pharmacokinetic parameters in final model
| Parameter | Parameter value | RSE (%) | 95% CI |
|---|---|---|---|
| Fixed effects | |||
| Ktr (1 h−1) | 4.70 | 31.1 | (1.84, 7.56) |
| CL/F (l h−1) | 24.6 | 22.0 | (14.0, 35.2) |
| Vc/F (l) | 10.3 | 45.1 | (1.20, 19.4) |
| Q/F (l h−1) | 7.51 | 38.9 | (1.78, 13.2) |
| Vp/F (l) | 14.5 | 35.4 | (4.44, 24.6) |
| Random effects | |||
| ω2 (IIV F; %) | 47.2 | 55.2 | (−3.87, 98.3) |
| ω2 (IIV Ktr; %) | 65.4 | 54.7 | (−4.72, 136) |
| ω2 (IOV F; %) | 46.4 | 87.0 | (−32.7, 126) |
| ω2 (IOV Ktr; %) | 67.8 | 63.2 | (−16.2, 152) |
| Residual variability | |||
| σ2 | 48.4 | 21.3 | (28.2, 68.6) |
CL/F, apparent clearance; IIV, interindividual variability; IOV, intra-occasional variability; Ktr, transit rate constant; Q/F, apparent intercompartmental clearance; RSE, relative standard error; Vc/F, apparent central volume of distribution; Vp/F, apparent peripheral volume of distribution.