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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Br J Haematol. 2009 Aug 10;147(1):140–149. doi: 10.1111/j.1365-2141.2009.07843.x

Figure 1.

Figure 1

Promoter activity without (wild-type) and with rs884409 SNP. Wild-type or mutant rs884409 SNP luciferase reporter constructs were transiently transfected into Caco-2 cells and relative luciferase activity (RLU) was measured 48 hours later. rs884409 SNP is localized to nucleotide −326 relative to the TSS-1 and had a significant negative association with basal promoter activity (p=0.0043). Data are representative of two independent experiments measured in triplicate, presented as means ±SD and analyzed using 1-way ANOVA and Tukey’s post hoc test. Data is presented as % of Wild-type promoter activity set as 100.