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Different mechanisms for Eps15 ubiquitination. The E3 ligases Nedd4 and parkin ubiquitinate Eps15 by different mechanisms: Nedd4 needs to be ubiquitinated before binding to the Eps15-UIM can occur. Parkin contains a UBL domain which binds constitutively to the UIMs of Eps15. HECT and RING domains are indicated in their respective E3 ligases.
