Figure 1.
Nucleotide sequence of the promoter region of the human DJ-1 gene (GenBank Accession number AB045294) showing the positions of significant sites. The +1 indicates the transcription start site. The position of the 16 bp deletion sequence is indicated by a single underline and the Sp1 site by a double underline. The position of the 18 bp insertion/deletion polymorphism (g.168_185del) is indicated in blue font and the positions of the primers used to generate the luciferase constructs are shown in bold green font. The positions of putative cis-motifs (AhR/ARNT and HIF-1) present in the 16 bp deletion sequence are indicated by arrows.