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. 2009 Oct 12;9:362. doi: 10.1186/1471-2407-9-362

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Copyright ©2009 Tuomela et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of VEGF-C overexpression on PC-3 prostate tumor growth. The occurrence of subcutaneous tumors of both PC-3/VEGF-C (n = 8) and PC-3/mock (n = 12) was 100%. (A) Subcutaneous PC-3/VEGF-C tumors grew larger (1132 ± 34 mm³, gray bars) than PC-3/mock tumors (47 ± 7 mm³, black bars) at 4 weeks and the differences in tumor volumes between the groups were significant at all time points between 2 and 4 weeks (p < 0.001). (B) The occurrence of orthotopical tumors was 88% (n = 29 out of 33 mice) in the PC-3/VEGF-C group and 86% (n = 24 out of 28 mice) in the control group. The mean volume of the PC-3/VEGF-C tumors was 400 ± 17 mm³(n = 29) and in PC-3/mock tumors it was 48 ± 4 mm³(n = 24), p < 0.001.