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. 2009 Apr 14;20(5):497–510. doi: 10.1089/hum.2008.137

FIG. 2.

FIG. 2.

Effect of infusion site and vector dose on immunohistochemical distribution of GDNF protein and nigral TH staining. (A) Infusion of 75 μl of AAV2-GDNF into monkey putamen produced extensive expression of GDNF in putamen. The circle represents the approximate diameter of a human putamen for comparison (10 mm). The numbers in the gray dots indicate the concentration of GDNF, expressed as nanograms per milligram of protein. This section is from a monkey that received a high putaminal dose of AAV2-GDNF. (B) Low-dose (LD) AAV2-GDNF to putamen. (C) High dose of vector delivered to the SN. Note the prominent caudal staining. (D–G) Effect of AAV2-GDNF on nigral TH staining. GDNF expression increased TH staining independent of site (putamen or SN). HD increased TH more than did LD. Black bar in panel 2C represents a 2-mm segment applicable to panels B–G. The circle in panel A represents a 10-mm diameter centered on the infusion site.