Figure 1.
Schematic of genipin exposure over culture period. Control groups were not exposed to genipin. Study 1: Constructs were exposed to genipin continuously (Continuous Exposure) in the culture medium. Study 2: Constructs were exposed to genipin for 24 hours only (Brief Exposure) and tested 1 and 7 days later. Study 3: On day 42 dexamethasone was removed from the culture medium and constructs were exposed to genipin continuously for 1 week prior to a 3 day interleukin-1α (IL-1α) challenge.