Table 1.
Genotype | Strain | X-rays (Gy) |
No. mice |
CFE ± SE (%) |
Median MF (× 10−6) |
---|---|---|---|---|---|
p21+/+ (group 1) | 129 × C57 | 0 | 15 | 8.0 ± 2.2 | 17.5 |
P21+/+ (group 2) | 129 × C57 | 0 | 14 | 7.9 ± 1.2 | 20.3 |
p21+/+ (group 3) | 129 × C57 | 0 | 5 | 6.7 ± 1.1 | 19.5 |
p21−/− | 129 × C57 | 0 | 12 | 8.5 ± 0.8 | 8.4* |
p21 wt | 129 × C57 | 1 | 2 | 5.4 ± 0.7 | 18.1 |
p21−/− | 129 × C57 | 1 | 12 | 4.2 ± 0.4 | 13.9 |
p21 wt | 129 × C57 | 4 | 13 | 5.1 ± 0.7 | 17.1 |
P21+/− | 129 × C57 | 4 | 4 | 3.2 ± 0.3 | 30.8 |
p21−/− | 129 × C57 | 4 | 11 | 5.5 ± 0.5 | 10.0 |
CFE, colony-forming efficiency; MF, mutant frequency
P = 0.03, compared to p21+/+ group 1.