Table 2.
Spectrum of mutational pathways to APRT-deficiency
| Genotype | X-rays | N | No. DAPr clones |
No. PM/EI (%) |
No. MR (%) | No. del (%) |
Average ratio of MR |
|---|---|---|---|---|---|---|---|
| p21+/+ | 0 Gy (Group 1) | 13 | 60 | 29 (48) | 31 (52) | 0 (0) | 0.64 |
| 0 Gy (Group 2) | 14 | 69 | 24 (35) | 43 (62) | 2 (3) | 0.65 | |
| 0 Gy (Group 3) | 5 | 18 | 5 (28) | 13 (72) | 0 (0) | 0.72 | |
| 4 Gy | 10 | 16 | 4 (25) | 10 (63) | 2 (12) | 0.65 | |
| p21+/− | 4 Gy | 4 | 18 | 4 (22) | 14 (78) | 0 (0) | 0.74 |
| p21−/− | 0 Gy | 12 | 60 | 18 (30) | 38 (63) | 4 (7) | 0.63 |
| 1 Gy | 8 | 23 | 12 (52) | 10 (43) | 1 (5) | 0.33 | |
| 4 Gy | 11 | 29 | 11 (38) | 17 (59) | 1 (3) | 0.47 | |
PM/EI, putative point mutation/epigenetic inactivation; MR, mitotic recombination; del, deletion. Ratio of MR in each mouse was as (number of MR clones)/(number of DAPr clones analyzed). The average ratio is more representative of the distribution of MR in a group.