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. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: J Biomed Mater Res A. 2009 Dec;91(3):742–752. doi: 10.1002/jbm.a.32259

MMP-2 concentrations (pg/ml) over time from human monocytes in the presence of sIPNs with various wt% ratios of ligand-PEG grafted gelatin:PEGdA: 3:7 sIPN (), 4:6 sIPN (), or 5:5 sIPN (). Data are shown per ligand group and are expressed as mean ± s.d. Comparing within each time point and each ligand identity at p<0.001: i.) at 2 h, all ligand-PEG grafted 3:7 sIPNs showed a significantly lower concentration compared to that of 4:6 and 5:5 sIPNs and all except methoxy-PEG grafted 4:6 sIPNs showed significantly higher concentrations compared to 5:5 sIPNs while within 5:5 sIPNs, RGD-, PHSRN-PEG grafted sIPNs were significantly lower than methoxy-PEG grafted sIPNs; ii.) from 24 to 96 h, concentrations from all ligand-PEG grafted 4:6 sIPNs were significantly higher than all 3:7 sIPN and 5:5 sIPN samples except versus GGG-PEG grafted 5:5 sIPN at 96 h; iii.) at 168 h, all 4:6 sIPN samples showed significantly higher concentrations than all 3:7 and 5:5 sIPNs and all 3:7 sIPN samples were significantly higher than all 5:5 sIPN samples.

Inline graphic — MMP-2 concentrations (pg/ml) over time from human monocytes in the presence of sIPNs with various wt% ratios of ligand-PEG grafted gelatin:PEGdA: 3:7 sIPN (), 4:6 sIPN (), or 5:5 sIPN (). Data are shown per ligand group and are expressed as mean ± s.d. Comparing within each time point and each ligand identity at p<0.001: i.) at 2 h, all ligand-PEG grafted 3:7 sIPNs showed a significantly lower concentration compared to that of 4:6 and 5:5 sIPNs and all except methoxy-PEG grafted 4:6 sIPNs showed significantly higher concentrations compared to 5:5 sIPNs while within 5:5 sIPNs, RGD-, PHSRN-PEG grafted sIPNs were significantly lower than methoxy-PEG grafted sIPNs; ii.) from 24 to 96 h, concentrations from all ligand-PEG grafted 4:6 sIPNs were significantly higher than all 3:7 sIPN and 5:5 sIPN samples except versus GGG-PEG grafted 5:5 sIPN at 96 h; iii.) at 168 h, all 4:6 sIPN samples showed significantly higher concentrations than all 3:7 and 5:5 sIPNs and all 3:7 sIPN samples were significantly higher than all 5:5 sIPN samples.