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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Microb Pathog. 2009 Aug 27;47(5):243–251. doi: 10.1016/j.micpath.2009.08.005

Figure 2.

Figure 2

Survival of Swiss-Webster mice (n = 20/group) after challenge via the i.n. route to mimic pneumonic plague. Mice were inoculated with 2 × 103 CFU of the wild type (WT) or the Lcr+ Pgm+ mutant strain ΔYPO499-516 (T6SS) of Y. pestis CO92. At 24 hours of postinfection and for a total of 5 days, half of the mice were given a sub-inhibitory dose (0.3 to 0.5 mg/kg/day) of the antibiotic levofloxacin (lvfx). An additional group of mice (n = 10) received a treatment dose of 50 mg/kg/day of levofloxacin by the same schedule as for the treatment with the low dose of antibiotic.