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Intracellular viability of 26° C pre-grown Y. pestis CO92 wild type (WT) or the Lcr+ Pgm+ mutant strain ΔYPO499-516 (T6SS) in murine macrophage like cell line J774.A1. Multiplicity of infection (MOI) = 1. Results represent three separate experiments
| Number of bacteria (log10 CFU/well) | |||||||
|---|---|---|---|---|---|---|---|
| MOI 1 | Time (hours) | ||||||
| Strain | 0 | 4 | 8 | 12 | 16 | 20 | 24 |
| WT | 4.3±0.03 | 4.2±0.14 | 4.0±0.44 | 4.5±0.07 | 4.1±0.1 | 3.8±0.05* | 2.9±0.24* |
| T6SS | 4.7±0.05 | 4.6±0.24 | 4.7±0.09* | 4.6±0.14 | 4.5±0.1* | 4.2±0.19* | 4.4±0.09* |
p < 0.001
