. Author manuscript; available in PMC: 2010 Nov 1.

Published in final edited form as: Trends Immunol. 2009 Aug 21;30(11):531–537. doi: 10.1016/j.it.2009.07.004

Table 1.

Neutrophil proteins with alarmin activity

Neutrophil protein	Alarmin activity and receptor(s)
Neutrophil protein	APC recruitment		APC activation		Immune enhancement
	Activity	Receptor	Activity	Receptor	Immune enhancement
α-Defensins	+	GiPCR	+	Unknown	+
Cathelicidins	+	FPRL1	+	P2X7	+
		FPR2		TLR9
Lactoferrin	+	GiPCR	+	TLR4	+
HMGB1	+	RAGE	+	RAGE	+
		GiPCR		TLR2
				TLR4
				TLR9

Abbreviations: APC, antigen-presenting cell; FPR, formyl peptide receptor; FPRL1, FPR-like receptor 1; GiPCR, an unidentified Gαi-protein-coupled receptor; HMGB1, high-mobility group box-1 protein; RAGE, receptor for advanced glycation end-products; TLR, Toll-like receptor.