Fig. 6.
Effects of an oxidant stress on p38 MAPK phosphorylation in mammalian skeletal muscle. The extent of p38 MAPK Thr180/Tyr182 phosphorylation was measured in soleus muscle preparations from lean Zucker rats following 2-hr or 4-hr exposures to an oxidant stress (60-90 μM H2O2) in the presence of insulin (5 mU/ml). Values are means ± SE for 4-5 muscles per group. *p<0.05 vs. basal in the absence of H2O2. **p<0.05 vs. insulin-stimulated in the absence of H2O2.