Figure 2.

Amino acid alignment of the C type lectins in the CD94/NKG2 family and Ly-49A. Brackets indicate boundaries for the cytoplasmic, transmembrane, stalk, and carbohydrate recognition domains (CRD). Regions of identity are shaded for emphasis and include tryptophan and cysteine residues that are conserved in all C-type lectins as well as spacing (48, 49). Consensus ITIM (boldface type underlined), charged residues in transmembrane domain in mNKG2-D and mCD94 (circled), stop codon (∗), and potential N-linked glycosylation sites (♦♦♦) are shown. The 13-amino acid sequence present in the cytoplasmic domain of mNKG2-D but not hNKG2-D is doubly underlined.