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. 2009 Aug 10;587(Pt 19):4589–4603. doi: 10.1113/jphysiol.2009.176297

Figure 7. Effect of membrane voltage on fractional recovery from memantine and ketamine inhibition.

Figure 7

A and B, current traces recorded with the double-pulse protocol at −26 mV (A) and −106 mV (B) used to examine voltage dependence of memantine trapping. C and D, current traces recorded at −26 mV (C) and −106 mV (D) used to examine voltage dependence of ketamine trapping. E, the effect of membrane voltage on fractional recovery from inhibition by memantine and ketamine. Inhibitor concentrations used at each voltage are listed in Table 1. Data for memantine at −66 mV are replotted from Fig. 4D. There was a significant drug × voltage interaction; fractional recovery from inhibition by memantine but not ketamine depended significantly on voltage (two-way ANOVA). Fractional recovery differed significantly between drugs at each voltage; #significantly different from other two values for same drug (Bonferroni's post hoc tests).