Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Bortezomib induces cellular STAT3 activity. UM-22B cells were stably transfected with pLucTKSIE, which contains two copies of the STAT3-responsive hSIE element upstream from a luciferase reporter gene. The UM-22B/pLucTKSIE cells were treated with bortezomib (20 nmol/L) for the indicated lengths of time, followed by luciferase assays. The data are plotted as fold induction of luciferase activity relative to untreated cells. Columns, mean of three independent experiments; bars, SE.
