(A) BJAB and CHO-K1 cells were transfected with 10 or 1 μg of LMP2A, Lyn, Syk-Myc and c-Cbl-Flag, respectively. Cell lysates were immunoblotted with anti-LMP2A, Lyn, Syk or c-Cbl antibody to detect both endogenous and transfected expression. (B) BJAB cells were transfected with 10 μg of LMP2A, Ub-HA and c-Cbl-Flag, respectively. LMP2A immunoprecipitates were immunoblotted with anti-HA antibody to detect ubiquitin-conjugated LMP2A. Cell lysates were immunoblotted with anti-c-Cbl antibody. The data is the representative of four comparable experiments.