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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Nutr Res. 2009 Sep;29(9):664–670. doi: 10.1016/j.nutres.2009.09.008

Table 2.

The production of 4-oxo-retinoic acid (RA) and 18-hydroxy-RA from the incubation of RA (5 μmol/L) with liver microsomal fraction of ethanol-fed rats with or without vitamin E supplementation

Ethanol-fed + Vitamin E supplemented
Non-ethanol-
fed		 Ethanol-fed Ethanol-fed
+ Vitamin E
supplemented		 Add additional
α-tocopherol
(5 μmol/L)		 Add additional
α-tocopherol
(10 μmol/L)		 Add CYP
inhibitor
liarozole
(10 μmol/L)		 Add CYP inhibitor
chloromethiazole (5
μmol/L)
4-oxo-RA
(pmol/mg protein)		 8.3 ± 1.6 c 68.1 ± 7.2 a 65.4 ± 6.5 a 62.3 ± 7.7 a 64.4 ± 8.3 a 3.8 ± 0.6 d 31.4 ± 3.3 b
18-hydroxy-RA
(pmol/mg protein)		 9.2 ±2.1 c 54.6 ± 8.1 a 58.5 ± 4.9 a 59.4 ± 8.9 a 65.9 ± 9.5 a 5.1 ± 0.8 d 28.7 ± 4.9 b

Data represent three determinations from three rats. Values are expressed as means ± SD. Within rows, treatments not sharing the same superscript are significantly different from each other (P<0.05).