Table 3. Association of patient and tumour characteristics with urinary cathepsin D by univariate analysis.
| Cathepsin D concentration | |||
|---|---|---|---|
| Status | Median (range) (ng ml−1 μmolCr−1) | P -value (association) | P -value (trend) |
| Normal | 133.2 (40.2, 856.5) | 0.052a | |
| Benign | 177.6 (73.9, 536.0) | ||
| RCC | 178.0 (27.0, 4274.0) | ||
| Control | 144.3 (40.2, 856.5) | 0.113b | |
| Sex | 0.188 | ||
| Male | 145.5 (27.0, 4274.0) | ||
| Female | 200.0 (40.2, 1209.0) | ||
| Agec | 0.103c | 0.212 | |
| Grade | 0.854 | 0.577 | |
| 1or2 | 195.0 (27.0, 4274.0) | ||
| 3 | 178.0 (54.0, 3492.0) | ||
| 4 | 172.0 (41.0, 2180.0) | ||
| Sarcomatoid change | 0.032 | ||
| No | 171.0 (27.0,1789.0) | ||
| Yes | 380.0 (73.0,2180.0) | ||
| pT stage | 0.254 | 0.080 | |
| 1 | 172.0 (27.0, 4274.0) | ||
| 2 | 175.0 (70.0, 471.0) | ||
| 3 | 204.5 (48.0, 3492.0) | ||
| 4 | 836.0 (86.0, 1789.0) | ||
| CT T stage | 0.159 | 0.086 | |
| 1 | 161.0 (27.0, 4274.0) | ||
| 2 | 182.0 (27.0, 2180.0) | ||
| 3 | 325.0 (48.0, 912.0) | ||
| 4 | 139.0 (86.0, 802.0) | ||
| N stage | 0.001 | ||
| 0 | 165.0 (27.0, 4274.0) | ||
| 1/2 | 362.0 (60.0, 2180.0) | ||
| M stage | 0.034 | ||
| 0 | 169.0 (27.0, 4274.0) | ||
| 1 | 251.0 (60.0, 1789.0) | ||
| Overall stage | 0.216 | 0.043 | |
| I | 165.0 (27.0,4274.0) | ||
| II | 175.0 (70.0,376.0) | ||
| III | 164.5 (48.0,3492.0) | ||
| IV | 224.0 (60.0,1789.0) | ||
| Symptoms | 0.368 | 0.190 | |
| Local | 169.0 (27.0,4274.0) | ||
| Asymptomatic | 172.0 (33.0,3492.0) | ||
| Systemic | 226.5 (63.0,912.0) | ||
| Tumour size c | |||
| CT | 0.143c | 0.109 | |
| pathology | 0.115c | 0.173 | |
a
Refers to test comparing normal, benign and renal cell carcinoma (RCC) group.
b
Refers to test comparing control (normal and benign) with RCC group.
c
Spearman's rank correlation coefficient.
Age, sex and tumour-related factors relate to RCC group only. P-value (association) is result of test comparing distributions in groups under null hypothesis of them being identical and P-value (trend) is the result of a test under the null hypothesis of no trend in naturally ordinal groups.