Table 4. Univariate and multivariable pre-operative prognostic modelling results for all RCC patients with cathepsin D concentration for OS.
|
Univariate analysis
|
Multivariable analysis
|
|||||
|---|---|---|---|---|---|---|
| Characteristic | HR | 95% CI | P- value | HR | 95% CI | P- value |
| Cath-D (ng ml−1 μmolCr−1) | 1.360 | (1.069, 1.738) | 0.005 | 1.302 | (1.000, 1.696) | 0.050 |
| Age (yr) | 1.007 | (0.984, 1.034) | 0.607 | 1.004 | (0.969, 1.041) | 0.828 |
| Sex | ||||||
| M vs F | 1.655 | (0.922, 2.971) | 0.091 | 2.656 | (1.057, 6.675) | 0.038 |
| CT T stage | ||||||
| T2 vs T1 | 1.098 | (0.495, 2.436) | 0.819 | 0.525 | (0.104, 2.645) | 0.435 |
| T3/T4 vs T1 | 6.315 | (2.139, 18.642) | 0.001 | 5.450 | (1.004, 29.575) | 0.049 |
| CT max. tumour diameter (cm) | 1.155 | (1.056, 1.263) | 0.002 | 1.041 | (0.821, 1.320) | 0.739 |
| M stage | ||||||
| M1 vs M0 | 4.623 | (2.657, 8.047) | 0.001 | 3.154 | (1.178, 8.449) | 0.022 |
| Symptoms | ||||||
| Local vs asymptomatic | 2.212 | (1.086, 4.505) | 0.029 | 1.230 | (0.470, 3.220) | 0.674 |
| Systemic vs asymptomatic | 4.127 | (2.008, 8.486) | 0.001 | 1.527 | (0.498, 4.683) | 0.459 |
Abbreviations: CI=confidence interval; HR=hazard ratio.