Figure 3.

Host-specific tumour progression. The values b and c in matrix (1) alter the position of the equilibrium on the osteoclasts (OC) to multiple myeloma (MM) line (A, B, C), whereas a and e change the equilibrium between OC and osteoblasts (OB) cells, producing deviations both in the disease path and on the characteristic evolutionary time scale. Each panel (A, B and C) shows a different path with the associated matrix, all leading to the same payoff matrix (2) with δ=10 and β=2. We start with a small perturbation of the OC–OB equilibrium and t₀ stands for the progression time of the configuration δ=10 and β=2 in payoff matrix (2) (Figure 2D).