Table 4. Non-haematologic toxicities (WHO grade) for TIP.
|
WHO grade (% of patients, all cycles)
|
|||||
|---|---|---|---|---|---|
| Toxicity | 0 | 1 | 2 | 3 | 4 |
| Nausea and vomiting | 24 | 41 | 13 | 22 | 0 |
| Mucositis | 72 | 28 | 0 | 0 | 0 |
| Myalgia/arthralgia | 50 | 17 | 33 | 0 | — |
| Neurologic | |||||
| Peripheral | 14 | 51 | 35 | 0 | 0 |
| CNS | 74 | 24 | 2 | 0 | 0 |
| Infection | 93 | 5 | 0 | 2 | 0 |
| Diarrhoea | 51 | 18 | 31 | 0 | — |
| Allergy | 93 | 7 | 0 | 0 | 0 |
| Alopecia | 0 | 0 | 15 | 85 | 0 |
| Asthenia/fatigue | 16 | 38 | 31 | 15 | — |
| Cardiac | 98 | 2 | 0 | 0 | 0 |
| Renal | 96 | 2 | 2 | 0 | 0 |
| Haematuria | 98 | 2 | 0 | 0 | 0 |
| Electrolytea | 95 | 5 | 0 | 0 | 0 |
Abbreviations: CNS=central nervous system; TIP=paclitaxel–ifosfamide–cisplatin; WHO=World Health Organization.
a
Electrolyte toxicity refers to serum potassium (K+) and magnesium (Mg2+) drop.