Table 1. AKT family mutations found in endometrial cancer.
| Gene | Sample ID | Mutation | Domain | PIK3CA amplification a | Other mutations |
|---|---|---|---|---|---|
| AKT1 | 436T | E17K | Pleckstrin homology | No | KRAS (G13D) |
| AKT2 | 288T | D399N | Regulatory C-terminal | No | PTEN (D24Y, F341Y, R130Q) |
| AKT2 | 426T | R368C | Catalytic kinase | No | CTNNB1 (S37Y) |
| AKT2 | 141T | D32Hb | Pleckstrin homology | No | PTEN (R130Q) |
| AKT3 | 192T | E438D | Regulatory C-terminal | Yes | PTEN (R130Q), PIK3CA (R88Q) |
a
Determined by segmentation analysis of normalised signal intensities from 100K single-nucleotide polymorphism arrays as previously reported (Salvesen et al, 2009).
b
Candidate mutation not validated by mass spectrometric genotyping.