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. 2009 Sep 29;101(7):1100–1106. doi: 10.1038/sj.bjc.6605296

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Copyright © 2009 Cancer Research UK

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Effect of Ki23057 on VEGFR-3 phosphorylation. (A) The ability of Ki23057 to inhibit VEGFR-3 phosphorylation was evaluated using human umbilical vein endothelial cells (HUVECs) that express the RTK of VEGFR-3. Ki23057 inhibited the tyrosine phosphorylation of VEGFR-3 with IC₅₀ values of 4.3 nM. (B) For cellular assay, HUVECs were incubated with serial concentrations of Ki23057. Ki23057 inhibited the growth of HUVEC with VEGFR-3 activated by VEGF-C. Ki23057 inhibited the autophosphorylation of VEGFR-3 at a dose-dependent manner. IC₅₀ kinase value was estimated as 37 nM.