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. 2009 Sep 29;101(7):1100–1106. doi: 10.1038/sj.bjc.6605296

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Copyright © 2009 Cancer Research UK

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Effects of Ki23057 in diffuse-type gastric carcinoma with lymph node metastasis. (A) Macroscopic findings of gastric tumours with lymph node metastasis. The orthotopic inoculation showed diffuse-type gastric tumours (arrowheads). The area of the orthotopically transplanted tumours in Ki23057-treated mouse (right panel) was less than that of the control (left panel). Large LN metastases (arrows) in control mice were recognised around the primary gastric tumour. Lymph node metastases in Ki23057-treated mice were fewer in number and smaller than in controls. No toxicity or body weight loss was observed in any of the groups. (B) H&E staining and Masson trichrome staining. Orthotopic tumours of OCUM-2MLN cells showed extensive fibrosis with the occasional presence of poorly differentiated adenocarcinoma cells that resembled DGC. Extensive stromal fibrosis was also found in OCUM-2MLN gastric tumours treated by Ki23057. No remarkable difference was found in the histological findings of orthotopic carcinomas between the control and Ki23057-treated mice by H&E staining. (C) The mean areas of the orthotopically transplanted tumours in the control and Ki23057-treated mice were 15 and 6 mm², respectively. Primary gastric tumours in mice receiving Ki23057 (25 mg kg⁻¹ day⁻¹) were significantly (P=0.008) smaller than those in controls. (D and E) The mean weights of metastatic LN in the control and Ki23057-treated mice were 91 and 11 mg, respectively. The mean number of metastatic LN in the control and Ki23057-treated mice were 7.8 and 1.5, respectively. Ki23057 significantly decreased both the mean weight (P<0.0001) and the mean number (P<0.0001) of involved nodes.