Table 2. Activity of pazopanib, sunitinib, and sorafenib against purified kinases.

	Kiapp (nM)
Enzyme	Pazopanib	Sunitinib	Sorafenib
VEGFR-1	15	229	10
VEGFR-2	8	51	4
VEGFR-3	10	30	6
PDGFR-α	30	28	2
PDGFR-β	14	7	5
c-Kit	2.4	0.45	15
Flt-3	230	0.6	22

Abbreviations: K_i^app=apparent inhibition constant; PDGFR=platelet-derived growth factor receptor; VEGFR=vascular endothelial growth factor receptor.