Table 3.

PCs that display statistically significant differences between tissue diagnosed with dysplasia/CIS and normal tissues based on unpaired Wilcoxon Rank Sum tests of PCs derived from spectra measured with the (a) shielded and (b) unshielded probe geometries. The PCs were derived from either the original spectra (original), spectra preprocessed by normalization to the peak (peak) or normalization to the area (area). Each PC is shown for the highest significance level (lowest p-value) that it satisfies.

(a)
Normalization Technique		Original	Peak	Area	Peak	Area
p-value		p<0.05			p<0.005
Excitation Wavelength (nm)	300			PC2	PC3
				PC3
	320	PC1	PC1	PC4		PC1
			PC2
			PC3
	340	PC1	PC1	PC3		PC1
			PC2
	370		PC2	PC2	PC1	PC1
			PC5	PC5
	410			PC2	PC2
	460
Reflectance (300–550 nm)		No reflectance measurements were made with the shielded probe

(b)
Normalization Technique		Original	Peak	Area	Original	Peak	Area	Original	Peak	Area
p-value		p<0.05			p<0.005			p<0.0005
Excitation Wavelength (nm)	300	PC1	PC1	PC1					PC3
	320					PC1	PC1	PC1	PC2	PC2
	340	PC2	PC1			PC2	PC1	PC1
							PC2
	370								PC1	PC1
	410		PC2				PC2		PC3	PC3
	460
Reflectance (300–550 nm)		PC4			PC3	PC4	PC3		PC1