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. Author manuscript; available in PMC: 2009 Oct 27.
Published in final edited form as: J Pharmacol Exp Ther. 2008 Aug 28;327(3):910–917. doi: 10.1124/jpet.108.144865

Fig 3. Acute EtOH exposure increases sIPSC frequency.

Fig 3

A. Sample sIPSC traces obtained under control conditions, in the presence of 50 mM EtOH, and after washout. Subsequently, TTX (0.5 μM) was applied to block action potential dependent IPSCs. At the end of the recording, bicuculline (20 μM) was applied to block GABAA receptors. B. Cumulative probability plots for sIPSC inter-event interval and amplitude corresponding to the recording shown in panel A. EtOH induced a significant (p< 0.0001 by K-S test) shift to the left in the inter-event interval cumulative probability plot. The amplitude cumulative probability plot was not significantly affected. C. Average superimposed sIPSC traces, corresponding to the recording shown in panel A, illustrating that 50 mM EtOH did not affect the amplitude or the decay of these events. D. Summary graph illustrating the effect of 50 mM EtOH and 0.5 μM TTX on sIPSC frequency and amplitude. The effect of EtOH was calculated with respect to the average of control and washout responses whereas the effect of TTX was calculated with respect to the washout responses (represented by the dotted line). ***p<0.001 by one sample t-test vs. a theoretical mean of 100% (n = 6 for EtOH and n = 5 for TTX).