FIGURE 7.

Virus-specific immune responses induced by vaccination. CD4⁺ and CD8⁺ T cell responses (A and B, respectively) measured as IL-2 or TNF-α and IFN-γ production following vaccination and ART suspension were evaluated in the same macaques used in Fig. 6D whose viremia remained suppressed during ART. These animals were selected to limit the confounding factor of overt viral replication on the vaccine immunogenicity. In these experiments, almost the entire SIV proteome was used as stimulus.