Figure 5.

Frozen liver section of control dog and naturally infected dogs (a,b) Control dog: laminin was weakly detected discontinuously, mainly in the walls of the central veins and perisinusoidal spaces (arrows). (c,d) Asymptomatic dog: (c) Presence of laminin around vessels (arrows); (d) an intralobular granuloma with a few positive cells for laminin (arrowheads). (e,f) Symptomatic dog: Diffuse laminin expression around the sinusoids (arrowheads). At the right corner, an intralobular granuloma with amastigotes forms of Leishmania can be observed (arrow), (f) Note strong laminin expression around the sinusoids (arrowheads). Immuno-streptoavidin-peroxidase method (Bars = 16 μm).