FIG. 3.

MCK-IL10 mice are more insulin sensitive and are protected against diet-induced insulin resistance in skeletal muscle. MCK-IL10 and WT mice were fed HFD for 3 weeks, and hyperinsulinemic-euglycemic clamps were performed in conscious mice to measure insulin action. Energy balance was measured for 3 days using metabolic cages. A: Daily food intake in standard diet– and HFD-fed mice. □, WT; ■, MCK-IL10. B: Vo₂ consumption. C: Physical activity. D: Whole-body fat mass. E: Basal (overnight-fasted) plasma glucose levels. F: Basal plasma insulin levels. G: Glucose infusion rates during hyperinsulinemic-euglycemic clamps. H: Insulin-stimulated whole-body glucose turnover. I: Insulin-stimulated glucose uptake in skeletal muscle. Values are means ± SE for six to eight mice in each experimental group. *P < 0.05 vs. WT mice fed respective diet. A two-way ANOVA was used for statistical analysis.